Age Support Science Review

Bakuchiol Science Review 

  • Summary of primary research when available.
  • We will not review animal studies and if we find any published literature that uses animals we first make sure that our supplier was not associated.
  • We exclude trials on products with multiple active ingredients as they are usually designed to validate a specific mixture created by another skincare line.
  • Updated as new information becomes available.


These 4 Performance Botanicals are used in our Bakuchiol Age Support Elevated Face Oil


  • Bakuchiol had comparable effect to retinol with improved tolerability 
    • 44 humans, blinded, randomized, 0.5% vs. 0.5%, 12 weeks of use (B1)
  • Similar effects on gene expression and stimulation of collagen
    • In vitro, side-by-side, human dermal fibroblasts and full thickness skin substitutes (B2) 
  • Improved elasticity, firmness, lines/wrinkles, and pigmentation; without undesirable effects
    • 17 humans, 0.5%, 12 weeks of use (B2) 
  • Improved smoothness, feel, clarity, radiance, and increased measurable moisture content. Well tolerated by a panel with eczema, atopic dermatitis, rosacea, and cosmetic intolerance syndrome 
    • 60-humans with sensitive skin, 1%, 4 weeks of use (B3)   
  • Significant reduction in acne lesions, improved appearance of scars, tolerated well. 
    • 13 humans with acne and post-inflammatory hyperpigmentation (predominantly skin of color), 0.5%, 12 weeks of use (B4) 
  • Improved skin remodeling, firmness, radiance. Measurable decrease in eye-area droopiness and wrinkle depth. Well tolerated.
    • 43 white humans, mixed skin types, Age 45+, bakuchiol 1.5%, 56 days of use (B5)
  • Significant reduction in acne and post inflammatory hyperpigmentation. Well tolerated.
    • 13 humans, all skin colors, moderate acne, 0.5% twice daily use for 12 weeks (B6)
  • In a lab experiment, Bakuchiol was found to significantly inhibit growth of p acnes, staph aureus, staph epidermidis, and candida albicans (B7) 
  • 1% Bakuchiol found to reduce acne lesions better than 2% salicylic acid (B7)
    • 13 humans in Bakuchiol group, 14 humans in Salicylic acid group, 15 humans in the control group. Results started to be seen after as early as 2 weeks of use and continued to increase for 6 weeks.
    • There was also a 15 human group that used a combination of Bakuchiol and salicylic acid and they saw the most significant reduction in their acne lesions.
  • Bakuchiol Supplier Information

Imperata Cylindrica

  • Supplier Information This is a link to the water soluble product. We use a preservative free, oil based version.
  • Described as working to draw water into the skin for long lasting hydration. The mechanism is felt to be due to a combination of potassium and a phytochemical called DMSP. Together they work to enhance osmosis and increase intracellular water content. 

Date Seed Extract

  • Improvement in facial skin hydration, elasticity, melanin, wrinkle size and depth. Well tolerated without side effects.
    • 43 humans, twice daily use for 8 weeks (D1)
  • Reduced surface wrinkles by 27.6%, reduced wrinkle depth by 3.52%. 60% of the participants felt results were noticeable.
    • 10 women aged 46-58, twice daily use for 5 weeks (D2)
  • Supplier Information

Sweet White Lupine Seed Extract

  • Supplier Information: Described as a patented active molecule that works to improve the look of wrinkles and sagging skin.


Bakuchiol Age Support Science Review Reference List


Alsohaimi A, Fouda AM. Assessment of the Effect of Extract Formulation of Date Palm Kernel on Facial Skin Wrinkles: Biophysical Measurements and Digital Profilometry. J Cosmet Sci. 2019 Nov/Dec;70(6):277-290. PMID: 31829921.


Bauza E, Dal Farra C, Berghi A, Oberto G, Peyronel D, Domloge N. Date palm kernel extract exhibits antiaging properties and significantly reduces skin wrinkles. Int J Tissue React. 2002;24(4):131-6. PMID: 12779247.


Dhaliwal S, Rybak I, Ellis SR, Notay M, Trivedi M, Burney W, Vaughn AR, Nguyen M, Reiter P, Bosanac S, Yan H, Foolad N, Sivamani RK. Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing. Br J Dermatol. 2019 Feb;180(2):289-296. Epub 2018 Sep 21. 


Chaudhuri RK, Bojanowski K. Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects. Int J Cosmet Sci. 2014 Jun;36(3):221-30. Epub 2014 Mar 6. 


Draelos ZD, Gunt H, Zeichner J, Levy S. Clinical Evaluation of a Nature-Based Bakuchiol Anti-Aging Moisturizer for Sensitive Skin. J Drugs Dermatol. 2020 Dec 1;19(12):1181-1183.


Brownell L, Geen S, E Y, Lee WL. A Clinical Study Evaluating the Efficacy of Topical Bakuchiol (UP256) Cream on Facial Acne. J Drugs Dermatol. 2021 Mar 1;20(3):307-310.


Bacqueville, D., Maret, A., Noizet, M., Duprat, L., Coutanceau, C., Georgescu, V., Bessou-Touya, S., & Duplan, H. (2020). Efficacy of a Dermocosmetic Serum Combining Bakuchiol and Vanilla Tahitensis Extract to Prevent Skin Photoaging in vitro and to Improve Clinical Outcomes for Naturally Aged Skin. Clinical, cosmetic and investigational dermatology, 13, 359–370.


Brownell L, Geen S, E Y, Lee WL. A Clinical Study Evaluating the Efficacy of Topical Bakuchiol (UP256) Cream on Facial Acne. J Drugs Dermatol. 2021 Mar 1;20(3):307-310.

B7 Chaudhuri, Ratan & Marchio, Francois. (2011). Bakuchiol in the management of acne-affected Skin. Cosmet. Toiletries. 126. 502-510.